Taking high-dose vitamin D supplements for five years did not affect the incidence of cardiovascular disease or cancer

Journal Reference: Jyrki K Virtanen, Tarja Nurmi, Antti Aro, Elizabeth R Bertone-Johnson, Elina Hyppönen, Heikki Kröger, Christel Lamberg-Allardt, JoAnn E Manson, Jaakko Mursu, Pekka Mäntyselkä, Sakari Suominen, Matti Uusitupa, Ari Voutilainen, Tomi-Pekka Tuomainen, Sari Hantunen. Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Triala randomized controlled trial. The … Read more

Findings open the way to more precise diagnoses and treatments of Alzheimer’s disease

Journal Reference: Chae Kim, Tracy Haldiman, Sang-Gyun Kang, Lenka Hromadkova, Zhuang Zhuang Han, Wei Chen, Frances Lissemore, Alan Lerner, Rohan de Silva, Mark L. Cohen, David Westaway, Jiri G. Safar. Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease. Science Translational Medicine, 2022; 14 (626) DOI: 10.1126/scitranslmed.abg0253 The researchers found a … Read more

One autoimmune disease could lead to another

Journal Reference: V. Michael Holers, Francisco G. La Rosa, Nirmal K. Banda. A Potential New Mouse Model of Axial Spondyloarthritis Involving the Complement System. Immune Network, 2021; 21 (6) DOI: 10.4110/in.2021.21.e45 The scientists serendipitously found that mice with antibody-induced rheumatoid arthritis in their joints went on to develop spinal lesions similar to those in axial … Read more

Neuroprotective mechanism altered by Alzheimer’s disease risk genes

Journal Reference: Matthew J. Moulton, Scott Barish, Isha Ralhan, Jinlan Chang, Lindsey D. Goodman, Jake G. Harland, Paul C. Marcogliese, Jan O. Johansson, Maria S. Ioannou, Hugo J. Bellen. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes. Proceedings of the National Academy of Sciences, 2021; 118 (52): e2112095118 DOI: … Read more

Disarming a blood-clotting protein prevents gum disease in mice

Journal Reference: Lakmali M. Silva, Andrew D. Doyle, Teresa Greenwell-Wild, Nicolas Dutzan, Collin L. Tran, Loreto Abusleme, Lih Jiin Juang, Jerry Leung, Elizabeth M. Chun, Andrew G. Lum, Cary S. Agler, Carlos E. Zuazo, Megan Sibree, Priyam Jani, Vardit Kram, Daniel Martin, Kevin Moss, Michail S. Lionakis, Francis J. Castellino, Christian J. Kastrup, Matthew J. … Read more

Prostate cancers linked to exposure to pesticides recognized as an occupational disease

Prostate cancers linked to exposure to pesticides recognized as an

Demonstration against the threat of prescription of the health scandal file related to chlordecone, in Fort-de-France, Martinique, February 27, 2021. LIONEL CHAMOISEAU / AFP Prostate cancers linked to occupational exposure to pesticides are now recognized as an occupational disease, according to a decree published on Wednesday, December 22, Official newspaper. This decision was “Expected, particularly … Read more

Greater exposure to nitrogen dioxide linked to higher levels of biomarkers of Alzheimer’s disease in the brain

Greater exposure to nitrogen dioxide linked to higher levels of biomarkers of Alzheimer’s disease in the brain – NovLink Home Mash I Greater exposure to nitrogen dioxide linked to higher levels of biomarkers of Alzheimer’s disease in the brain We wish to thank the writer of this post for this remarkable material Greater exposure to … Read more

Gum disease increases risk of other illness such as mental health and heart circumstances, study suggests

Gum disease increases risk of other illness such as mental health and heart circumstances, study suggests – NovLink Home Mash E Gum disease increases risk of other illness such as mental health and heart circumstances, study suggests We wish to thank the writer of this post for this amazing content Gum disease increases risk of … Read more

Scientists develop new gene therapy for eye disease

Journal Reference: Daniel M. Maloney, Naomi Chadderton, Sophia Millington-Ward, Arpad Palfi, Ciara Shortall, James J. O’Byrne, Lorraine Cassidy, David Keegan, Peter Humphries, Paul Kenna, Gwyneth Jane Farrar. Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction. Frontiers in Neuroscience, 2020; 14 DOI: 10.3389/fnins.2020.571479 The study, which involved a collaboration with … Read more

Experimental gene therapy reverses sickle cell disease for years

Journal Reference: Julie Kanter, Mark C. Walters, Lakshmanan Krishnamurti, Markus Y. Mapara, Janet L. Kwiatkowski, Stacey Rifkin-Zenenberg, Banu Aygun, Kimberly A. Kasow, Francis J. Pierciey, Melissa Bonner, Alex Miller, Xinyan Zhang, Jessie Lynch, Dennis Kim, Jean-Antoine Ribeil, Mohammed Asmal, Sunita Goyal, Alexis A. Thompson, John F. Tisdale. Biologic and Clinical Efficacy of LentiGlobin for Sickle … Read more

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